No, only users can be inactivated.
Workaround
Remove the group from the top level collections to prevent it from being inherited by child collections and then to apply the change to all child collections.
Warning: Depending on the number of Collections and size of the site an ACL Change like this may not be possible without failing or taking hours or days to complete.
An alternative approach might be to subdivide the tree for this kind of change and do several smaller cascades, maybe one each night for several nights. That is, identify sub trees to do the change with cascade, and for the upper levels, just change those individually without cascade.
For example: If you have 4 top level collections (level 1), each of which has 6 sub collections (level 2), each of which has a sub tree of ten thousand things under it. You could do a change ACL and cascade on each of the level 2 collections, then go back and change ACL without cascade on the level 1 collections.
Note: If this is a requirement customer may need to engage DocuShare Professional Services.
Solution Published: June 30th, 2014
Solution ID: 1509